I think there will definitely be another series and probably sooner then there should be, there's just too much money involved for Paramount (or whoever makes the decisions) to sit on it for too long.
It will be interesting to see what new angle they try to put on it, maybe the first series not centred on the Federation? I doubt they'd go so far as to make an alien race the central characters but some other type of crew living in and dealing with the federation might be interesting.
Although you never know, a Klingon-based show would certainly get alot of initial press but can you imagine the make-up department
I know it probably wouldn't happen but a mini-series based on one of the introduced aliens might work well.
What ever it is I just hope it's not Star Trek Academy which I think has been raised before, although it could be done well I'm sure the temptation would be too great and we'd end up with
Star Trek 90210.
More than likely though it'll be something less diferent and easier for tie-ins, what are the odds that Jonathan Frakes has been offered to continue his role with his new command as the central storyline?