I'd skip the real hotel idea too. If something ever did happen to that particular real hotel, guess what will be brought up - your book!
If immediate drama, I'd do hotel. A house is small, people (if awake and at a party) are much more likely to be able to escape, it's usually not far from any particular location to a door or window, and most parties take place downstairs. With a hotel you could be several floors from an exit, and would have no clear idea of where you needed to go to get out.
If loss and emotional consequence AFTER the fire, I'd go with house.
Hope this helps!